Selected Publications

Rana, M.K., Aloisio, F.M., Choi C., Barber, D.L. 2018. Formin-dependent TGF-β signaling for epithelial to mesenchymal transition. Mol. Biol. Cell 29:1465-1475.

White, KA, Grillo-Hill, BK, Esquivel, M, Peralta, J, Bui, VN, Chire, I, Barber, DL. 2017 β-catenin is a pH sensor with decreased stability at higher intracellular pH. J .Cell Biol. 217(11):3965-3976.

Vercoulen, Y., Kondo, Y., Iwig, J.S., Janssen, A, White, K.A,, Barber, D.L. Kuriyan, J. and Roose, J.P. 2017 A Histidine pH Sensor Regulates the Activation of the Ras-specific Guanine Nucleotide Exchange Factor RasGRP1. eLife 6:e29002.

Tatapudy, S., Aloisio, F., Barber, D.L., Nystul, T. 2017 Cell fate decisions: emerging roles for metabolic signals and cell morphology. EMBO Reports 18(12):2105-2118.

White, K.A., Garrido Ruiz, G., Szpiech, Z.A., Strauli, N.B., Hernandez, R.D., Jacobson, J.P. and Barber, D.L. 2017 Arginine to histidine cancer mutations confer a gain in pH sensing to mutant proteins. Sci Signaling 10(495). pii: eaam9931.

Webb, B.A., Dosey, A.M., Wittmann, T., Kollman, J, and Barber, D.L 2017 Filament assembly by the glycolytic enzyme phosphofructokinase-1. J Cell Biol 216:2305-2313. (Spotlight article in Journal “Strength in numbers: Phosphofructokinase polymerization prevails in the liver” 216:2239-2241).

White, K.A., Grillo-Hill, B.K., Barber, D.L. 2017. Dysregulated pH dynamics enables cancer cell behaviors. J. Cell Sci. 130:663-669

Webb, B.A., White, K.A., Grillo-Hill, B.K., Schonichen, A., Cho, C., Barber, D.L. 2016. A histidine cluster in the cytoplasmic domain of the Na-H Exchanger NHE1 confers pH-sensitive phospholipid binding and regulates transporter activity. J. Biol. Chem. 291:24096-24104.

Ulmschneider, B., Grillo-Hill, B.K., Benitez, M., Azimova, D., Barber. D.L., Nystul, T.G. 2016 Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation. J. Cell Biol 215:345-355 (featured focus article in journal)

Webb, B.A.*, Forouhar, F.*, Szu, F.E., Seetharaman J., Tong L.,** Barber, D.L.** 2015 Crystal structures of human phosphofructokinase-1 and atomic basis of cancer mutations. Nature 523:111-114. *co-first authors, ** co-corresponding authors

Grillo-Hill, B.K., Choi, C., Jimenez-Vidal, M. and Barber D. L. 2015 Increased H+ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression. eLife 4:e03270.

Rana, M.K., Srivastava, J., Yang, M., Chen, C.S. and Barber, D.L. 2015 Hypoxia increases fibronectin deposition but not assembly during epithelial cell transdifferentiation. J Cell Sci 128(6):1083-1089. (Featured highlight in journal)

LeClaire, L.L., Rana, M.K., Baumgartner, M. and Barber, D.L. 2015 Arp2 phosphorylation: Functional significance and regulation by the Nck-interacting kinase NIK. J. Cell. Biol. 208:161-170. (Highlighted commentary in Journal 208:138).

Choi, C.C., Webb, B.A., Chimenti, M., Jacobson, M.P. and Barber, D.L. A molecular mechanism for pH sensing by FAK in focal adhesion remodeling. J Cell Biol. 2013 202:849-59. (Highlighted commentary in Journal 202:833-836; Commentary in Cell Migration Gateway, K. Legg, "Factoring pH into FAK phosphorylation", cited in Faculty of 1000 Prime).

Schönichen, A., Webb, B.E., Jacobson, M.P., and Barber, D.L. Considering protonation as a post-translational modification regulating protein structure and function. Ann Rev Biophys. 2013 42:289-314.

Choi, C.C.,* Thomason, P.A.,* Zaki, M., Insall, R.H., and Barber, D.L. Phosphorylation of actin-related protein 2 (Arp2) is required for normal development and cAMP chemotaxis in Dictyostelium (authors contributed equally) J Biol Chem. 2013 288:2464-74.

Haynes, J., Srivastava, J., Madson, N., Wittmann, T., and Barber, D.L 2011 Dynamic actin remodeling during epithelial-mesenchymal transition depends on increased moesin expression. Mol Biol Cell. 22:4750-4764. 

Narayanan, A., LeClaire, L.L., Barber, D.L. and Jacobson, M.P. 2011 Phosphorylation of the Arp2 Subunit Relieves Auto-inhibitory Interactions for Arp2/3 Complex Activation. PLoS Comput Biol. 7:e1002226. 

Webb, B.E., Chimenti, M., Jacobson, M.P., and Barber, D.L. 2011 Dysregulated pH: a perfect storm for cancer progression. Nature Cancer Rev. 11:671-677. 

Choi, C.C., Patel, H., and Barber, D.L 2010 Expression of actin-interacting protein 1 suppresses impaired chemotaxis dictyostelium cells lacking the Na-H Exchanger NHE1 Mol. Biol. Cell. 21(18):3162-3170.

Meima, M.E., Webb, B.E., Witkowska, H.E., and Barber. D.L. 2009 The Na-H exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors. J. Biol. Chem. 284(39):26666-26675.

Frantz, C., Barreiro, G., Dominguez, L., Chen, X., Eddy, R., Condeelis, J., Kelly, M., Jacobson, M., and Barber, D.L. 2008 Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding. J. Cell Biol. 183:865-879 (Highlighted in Journal; Cited in Faculty of 1000, Factor 8.0).

Srivastava, J., Barreiro, G., Groscurth, S., Gringas, A.R., Goult, B.T., Critchley, D.R., Kelly, M.J.S, Jacobson. M.P., and Barber, D.L. 2008 Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling. Proc. Natl. Acad Sci. 105:14436-14441.

LeClaire, L.L. III, Baumgartner, M., Iwasa, J.H., Mullins, R.D., and Barber, D.L. 2008 Phosphorylation of the Arp2/3 complex is necessary to nucleate actin filaments. J. Cell Biol. 182:647-654. (Highlighted in Journal; Cited in Faculty of 1000, Factor 8.0) 

Frantz, C., Karydis, A., Nalbant, P., Hahn, K.M., and Barber, D.L. 2007 Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells. J. Cell Biol. 179:403-410. (Highlighted in Journal) 

Baumgartner, M., Blackwood, E.M., Sillman, A., Srivastava, J., Madson, N., Schilling, J.W., Wright, J.H., and Barber, D.L. 2006 The Nck-interacting kinase NIK phosphorylates ERM proteins for formation of lamellipodium by growth factors. Proc. Natl. Acad. Sci. 103:13391-13396. 

Patel, H. and Barber, D.L. 2005 A developmentally-regulated Dictyostelium Na-H exchanger is necessary for cell polarity and chemotaxis. J. Cell Biol. 169:321-329.

Denker, S.P. and Barber, D.L. 2002 Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1. J. Cell Biol. 159:1087-1096. (Highlighted in Journal; Cited in Faculty of 1000, Factor 13)

Denker, S.P. Huang, D.C., Orlowski, J., Furthmayr, H., and Barber, D.L. 2000 Direct binding the Na-H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H+ translocation. Mol. Cell 6:1425-1436.